Professor Ji-Long Liu has relocated his research group from the University of Oxford to ShanghaiTech University in 2016. We are looking for a motivated and enthusiastic scientist to join Professor Ji-Long Liu’s research group in Shanghai.
The cytoophidium (plural “cytoophidia”), meaning the cellular snake in Greek, represents a novel type of organelles. In 2010, three groups including us discovered that CTP synthase is compartmentalised into the cytoophidium. Cytoophidia have existed on our planet for at least 3 billion years and are evolutionarily conserved from bacteria to human. Using the fruitfly Drosophila melanogaster, the fission yeast Schizosaccharomyces pombe and human cells as prime model systems, we will study the mechanisms by which metabolic enzymes such as CTP synthase and IMP dehydrogenase are compartmentalised within a cell. CTP synthase and IMP dehydrogenase have been attractive targets for developing agents against cancer, virus and parasites. We will investigate how various metabolic enzymes are assembled into cytoophidia and how the cytoophidium and its kind are linked to metabolic regulation and cancer biology.
The post holder will join a highly interactive research team working on metabolic cell biology. You will develop genetic and biochemical approaches to study the biology of the cytoophidium. The study of metabolic compartmentation by genetic and biochemical approaches promises to form a broad view on basic cellular questions, as well as sheds light on molecular mechanism of disease related to intracellular compartments.
The successful applicant should have a strong background in genetics, biochemistry and cell biology. Excellent organisational and communication skills will be required, together with the ability to work well within a team.
You will work in the School of Life Science and Technology (SLST) at ShanghaiTech University. SLST aims to develop into a world-class, research-oriented school in life science and technology. Additional information about Liu lab at ShanghaiTech, please click http://cytoophidia.org/