Postdoctoral Positions in Stem Cell Biology and Epigenetics: University of Wisconsin School of Medicine and Public Health (Dept. of Cell and Regenerative Biology; Carbone Cancer Center)

Description: The Bresnick laboratory is expanding our research group located in the Wisconsin Institutes of Medical Research (WIMR) and Carbone Comprehensive Cancer Center in the University of Wisconsin School of Medicine and Public Health. The WIMR is an outstanding collegial environment for conducting innovative and rigorous basic and translational research. Madison, Wisconsin is commonly ranked as an exceptional city to live, and the University of Wisconsin-Madison is highly ranked in numerous disciplines. Specific projects focus on hematopoietic stem/progenitor cell biology, vascular biology, and epigenetics. These efforts utilize multidisciplinary approaches (including genomics, proteomics, chemical genetics, molecular/cellular biology, and computational analysis) to understand important mechanistic, biological, and pathological processes. In addition to elucidating principles, we aim to develop innovative therapeutic strategies based on targeting novel mechanisms. A rigorous training plan is in place to ensure the effective career development of successful candidates.

1. Lee HY, Johnson KD, Fujiwara T, Boyer ME, Kim SI, Bresnick EH. Controlling hematopoiesis through sumoyation-dependent regulation of a GATA factor. Mol Cell 36:984-5, 2009.
2. Fujiwara T, O’Geen H, Keles S, Blahnik K, Linnemann AK, Kang YA, Choi K, Farnham PJ, Bresnick EH. Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell 36:667-81, 2009.
3. Fujiwara T, Lee HY, Kumar S, Bresnick EH. Building multifunctionality into a complex containing master regulators of hematopoiesis. Proc Natl Acad Sci 107: 20429-34, 2010
4. Li L, Jothi, R, Cui K, Lee JY, CohenT, Gorivodsky M, Tzchori I, Zhao Y, Hayes SM, Bresnick EH, Zhao K, Westphal H, Love, PE. Nuclear adapter Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells. Nat. Immunol. 12: 129-36, 2011
5. Lee HY, Johnson KD, Boyer ME, Bresnick EH. Relocalizing genetic loci into specific subnuclear neighborhoods. J Biol Chem 286: 18834-18844, 2011
6. Linnemann AK, O’Geen H, Keles S, Farnham PJ, Bresnick EH. Genetic framework for GATA factor function in vascular biology. Proc Natl Acad Sci USA 108: 13641-13646, 2011.
7. Kang Y-A, Sanalkumar R, O’Geen H, Linnemann, AK, Chang C, Bouhassira EE, Farnham PJ, Keles S, Bresnick EH. Autophagy driven by a master regulator of hematopoiesis. Mol Cell Biol 32: 226-239, 2011.
8. Johnson KD, Hsu A, Rhu M-J, Lee M, Gao X, Calvo K, Keles S, Zhang J, Holland SM, and Bresnick EH Cis-element mutation in GATA-2-dependent immunodeficiency governs hematopoiesis and vascular integrity. J Clin Invest 122: 3692-3704, 2012.

Qualifications: The successful candidate will be rigorously trained in relevant disciplines of biomedical science, highly motivated, capable of effectively contributing to multidisciplinary collaborations, will have published important first-author papers in English journals, and will not have engaged in prior postdoctoral work for more than three years.
Application Details: Applications should be sent to Emery H. Bresnick, Ph.D via e-mail at ehbresni@wisc.edu