Job Description
        The research focuses of Prof. Yujun Zhao's group mainly include: 1. Small molecule inhibitors of protein protein interactions; 2. Small molecule kinase inhibitors. Prof. Zhao is faculty in Shanghai Institute of Materia Medica, Chinese Academy of Sciences. He has published 32 papers and 7 PCT patents.Prof. Di Zhu ’s group in Fudan University has established assay cascade and animal models for development immunomodulator, and selected publication from his lab including, Science Advances, Signal Transduction and Targeted Therapy, Oncogene, British Journal of Pharmacology, etc. Now, the two research groups are jointly recruiting a postdoctoral fellow for small molecule development of protein protein interaction. This job is supported by Fudan University, and working site is located in Pudong New Area, Shanghai.Highly skilled and motivated synthetic organic/medicinal chemists are encouraged to apply. The responsibility of this position includes the design and synthesis of anti-cancer reagents.We are seeking a creative and highly motivated individual to join our medicinal chemistry group for a post-doctoral program. The ideal candidate should have strong modern synthetic chemistry skills. He/she is independent and experimentally skilled with abilities to execute syntheses, and analyze and troubleshoot synthetic results. Candidates must have ability to work effectively in a team environment.

Principal Duties and Responsibilities

• Design and synthesis of organic molecules that are applicable in medicinal chemistry
• Independently execute syntheses and characterize compounds utilizing analytical tools
• Devise methods and routes to address synthetic challenges
• Execute multi-step reaction optimization
• Discuss and communicate experimental results to supervisor and chemistry team in an appropriate, accurate and timely manner
• Contribute to manuscript preparation to publish experimental results
• Maintain high standards of laboratory safety, comply with H3 safety manual, and complete required training
• Maintain an accurate and current record of experimental results in laboratory notebook
• The successful candidate will also be encouraged to collaborate and consult with academic advisors as needed
• We desire an individual with attention to detail, motivation, independence, and ambition to further our mission to improve patient lives

Qualifications

• Ph.D. in organic chemistry or medicinal chemistry with 0-2 years of industrial experience in synthetic organic chemistry
• Comprehensive and up-to-date knowledge of synthetic organic chemistry reactions and mechanisms
• Strong synthetic skills in organometallic chemistry and methodology development
• Proven track record of accomplishments, as indicted by publications in the primary literature
• Good communication and writing skills in both Chinese and English, good academic ethics and integrity, able to adapt to fast-paced working environment, diligent and willing to work;
• Strong technical or experimental expertise and demonstrated ability to:
• Independently design efficient synthetic routes
• Independently execute syntheses of complex molecules
• Troubleshoot and optimize muti-step reactions based on hypotheses and reaction mechanism
• Work with minimal supervision and simultaneously balance multiple tasks
• Communicate effectively and present research results within the team

Benefits:

We provide a pre-tax annual salary of over 300,000 yuan and necessary research, experimental equipment and research funds, and assist you to apply for various funds. In addition, you may get extra bonus, if you acquire good research results. We will pay insurances and housing fund, additional performance, year-end bonus, annual leave, etc for employee. Candidates can also choose to enter Shanghai registered permanent residence, and can enjoy Shanghai rental subsidy with one-time payment.

Application method:

Individuals interested in this position are encouraged to submit their resume and research summary. Please send your resume and publications to: jxsywang@163.com.

Job Requirements:

Major requirements: Organic chemistry or pharmaceutical chemistry or related major;
Education Requirements: Doctoral degree;
Years of work: No limitation;
Professional title requirements: No limitation:
English Level: CET-6 or equivalent or above.

Job Description:
Prof. Di Zhu ’s group in Fudan University has established assay cascade and animal models for development immunomodulator, and selected publication from his lab including, Science Advances, Signal Transduction and Targeted Therapy, Oncogene, British Journal of Pharmacology, etc. Now, theresearch group is recruiting a postdoctoral fellow for pharmacological research of new drugs. This job is supported by Fudan University, and working site is located in Pudong New Area, Shanghai.Highly skilled and motivated tumor immunopharmacologist are encouraged to apply. The responsibility of this position includes pharmacologic evaluation of new anti-cancer drugs.We are seeking a creative and highly motivated individual to join our pharmacology group for a post-doctoral program. The ideal candidate should have strong modern tumor immunopharmacology skills. Candidates must have ability to work effectively in a team environment.
Principal Duties and Responsibilities

• Design and implement pharmacological experiments for new drugs
• Devise methods and routes to address pharmacology challenges
• Discuss and communicate experimental results to supervisor and pharmacology team in an appropriate, accurate and timely manner
• Contribute to manuscript preparation to publish experimental results
• Maintain high standards of laboratory safety, comply with H3 safety manual, and complete required training
• Maintain an accurate and current record of experimental results in laboratory notebook
• The successful candidate will also be encouraged to collaborate and consult with academic advisors as needed
• We desire an individual with attention to detail, motivation, independence, and ambition to further our mission to improve patient lives
  
  Qualifications
  

• Ph.D. in pharmacology with 0-2 years of related experience
• Comprehensive and up-to-date knowledge of pharmacology andmechanisms
• Strong pharmacology skills in new drugs evaluation and methodology development
• Proven track record of accomplishments, as indicted by publications in the primary literature
• Good communication and writing skills in both Chinese and English, good academic ethics and integrity, able to adapt to fast-paced working environment, diligent and willing to work;
• Strong technical or experimental expertise and demonstrated ability to:
• Independently design and executeprotocol
• Troubleshoot and optimize muti-step reactions based on hypotheses and reaction mechanism
• Work with minimal supervision and simultaneously balance multiple tasks
• Communicate effectively and present research results within the team

Two NIH funded postdoctoral fellow positions immediately available at Cleveland Clinic Lerner Research Institute Cancer Biology Department to develop novel treatment and treatment prediction markers in multiple myeloma.
Our laboratory focuses on the critical chromosomal translocations that drive multiple myeloma development, precision medicine, and immune therapy development. Via mechanistic dissection of B cell Class Switch Recombination (CSR) especially the error pronealternative NHEJpathway and/or somatic hyper mutation (SHM) pathway regulated by AICDA, we aim to develop novel therapeutic targets and immune treatment approaches and to identify biomarkers of response to targeted therapy. All projects involve conditional transgenic and xenograft mouse models of multiple myeloma and clinical validation of laboratory findings patient’s samples from multiple myeloma tissue bank and ongoing clinical trials. 
The position will provide a unique and multidisciplinary exposure to preclinical mouse models, molecular oncology, immune therapy, drug development and clinical trials.  Further details are available at:   https://www.lerner.ccf.org/cancerbio/zhao/
The ideal candidate has a M.D. or Ph.D. degree in clinical medicine, biochemistry or molecular biology; has the appropriate expertise in mouse model is highly encouraged to apply.  Outstanding verbal and communication skills are required. Interested applicants should submit a CV and contact information for 3 references to Dr. Jianjun Zhao via email: zhaoj4@ccf.org.